Title: Modulation of Motor Cortex Neuronal Activity and Motor Behavior 1 during Subthalamic Nucleus Stimulation in the Normal Primate 2 3 Authors and Affiliations: Stn Stimulation and M1 Activity in Normal Primate
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چکیده
1 during subthalamic nucleus stimulation in the normal primate 2 3 Authors and Affiliations: Luke A. Johnson, Weidong Xu, Kenneth B. Baker, Jianyu Zhang, Jerrold L. Vitek 4 Department of Neurology, University of Minnesota, Minneapolis, MN 55455 USA; 5 2 Department of Anesthesiology, Cleveland Clinic Foundation, Cleveland, OH 44195 USA; 6 7 Authors Contribution: W. Xu and J. Zhang conducted the experiments. L.A. Johnson analyzed the data and 8 prepared the manuscript. K.B. Baker and J.L. Vitek contributed to manuscript revisions. 9 10 Running Head: STN stimulation and M1 activity in normal primate 11
منابع مشابه
CALL FOR PAPERS Neurobiology of Deep Brain Stimulation Modulation of motor cortex neuronal activity and motor behavior during subthalamic nucleus stimulation in the normal primate
Johnson LA, Xu W, Baker KB, Zhang J, Vitek JL. Modulation of motor cortex neuronal activity and motor behavior during subthalamic nucleus stimulation in the normal primate. J Neurophysiol 113: 2549–2554, 2015. First published February 11, 2015; doi:10.1152/jn.00997.2014.— Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established surgical therapy for advanced Parkinson’...
متن کاملModulation of motor cortex neuronal activity and motor behavior during subthalamic nucleus stimulation in the normal primate.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established surgical therapy for advanced Parkinson's disease (PD). An emerging hypothesis is that the therapeutic benefit of DBS is derived from direct modulation of primary motor cortex (M1), yet little is known about the influence of STN DBS on individual neurons in M1. We investigated the effect of STN DBS, delivered at...
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Oscillatory neural activity in different frequency bands and phase-amplitude coupling (PAC) are hypothesized to be biomarkers of Parkinson's disease (PD) that could explain dysfunction in the motor circuit and be used for closed-loop deep brain stimulation (DBS). How these putative biomarkers change from the normal to the parkinsonian state across nodes in the motor circuit and within the same ...
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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in patients with Parkinson's disease (PD). STN-DBS enables similar improved motor function, including increased movement speed (reduced bradykinesia), in the 6-OHDA dopamine-depletion mouse model of PD. Previous analyses of electrophysiological recordings from STN and motor cortex (M1) have explored signaling ...
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Abstract Background: To improve the debilitating features of Parkinson disease (PD) different medical and surgical approaches are available. Subthalamic nucleus deep brain stimulation (STN-DBS) was appeared to be a promising method during last two decades. This study aimed to evaluate early motor outcomes of this procedure in first trial of Iranian patients . Methods: Thirty-seven...
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تاریخ انتشار 2015